Teripang dalam Era Onkologi Integratif: Prospek Bioterapi Kanker Hati
DOI:
https://doi.org/10.28932/jmh.v8i1.11741Keywords:
teripang, kanker hati, apoptosis, bioaktif laut, onkologi integratifAbstract
Teripang (Holothuroidea) merupakan invertebrata laut yang kaya akan senyawa bioaktif seperti triterpen glikosida, saponin, dan polisakarida, yang menunjukkan potensi terapeutik signifikan terhadap karsinoma hepatoseluler (HCC). Tulisan ini bertujuan untuk merangkum bukti terkini mengenai aktivitas farmakologis teripang serta menjelaskan mekanisme molekuler yang mendasari efek antikankernya. Berbagai studi eksperimental telah menunjukkan bahwa ekstrak teripang memiliki efek antiinflamasi, imunomodulator, antioksidan, dan antitumor melalui mekanisme induksi apoptosis, penghentian siklus sel, penghambatan angiogenesis, serta modulasi jalur pensinyalan onkogenik. Dalam konteks onkologi integratif, teripang semakin diakui sebagai agen adjuvan potensial karena memiliki sitotoksisitas selektif terhadap sel kanker dan kemampuan mengatur mikro lingkungan tumor. Akan tetapi masih terdapat berbagai tantangan, termasuk variasi antarspesies dalam kandungan senyawa bioaktif, keterbatasan data farmakokinetik, serta belum adanya standarisasi dosis dan validasi klinis. Simpulan, senyawa bioaktif yang berasal dari teripang merupakan sumber alami yang menjanjikan untuk pengelolaan HCC. Penelitian praklinis dan klinis yang dirancang dengan baik sangat diperlukan untuk memastikan efektivitas, keamanan, dan potensi translasi klinisnya dalam terapi kanker hati di masa depan.Downloads
References
Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A, et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2021;71(3):209–49.
Llovet JM, Kelley RK, Villanueva A, Singal AG, Pikarsky E, Roayaie S, et al. Hepatocellular carcinoma. Nat Rev Dis Primers. 2021;7(1):6–31.
Cigaral B, Prosse E, Tecino R, Bascon A, Lenero G, Fonsceca R, et al. Therapeutic protocol for liver cancer. Medicine (Baltimore). 2021;13(4):1353–6.
Fang Y, Piao Z, Zhang S, Huang F, Liu X, Chen J, et al. Current status of adjuvant-targeted immunotherapy after radical surgery for hepatocellular carcinoma. Chin J Clin Oncol. 2024;51(7):915–8.
Yu-Feng W, Dong-Fong H, Li M, Zhao L, Chen Y, Wen Z, et al. Research progress on transcatheter arterial chemoembolization combined with drugs for liver malignant tumors. Med J Chin PLA. 2022;47(5):524–32.
Wargaseta TL, Permana S, Widjajanti N, Lestari D, Raharjo E, Dewi PS, et al. Mechanisms of action of sea cucumber active compounds in hepatocellular carcinoma. Biomed J Indones. 2023;37(5):680–6.
Dejan F, Permana S, Widjajanti N, Sutisna T, Sasmita H, Lestari A, et al. Effectiveness of Holothuria scabra extract in animal models and experimental hepatocellular carcinoma. Asian J Health Sci. 2024;44(7):544–52.
Lu J, Liu Y, Fan K, Zhang Z, Wang X, Chen H, et al. Traditional Chinese medicine as a tool for the treatment of hepatocellular carcinoma. Front Pharmacol. 2021;12:703–41.
Seyid E, Motallebai A, Shahzabi N, Barzegar M, Rahimi T, Nematollahi S, et al. Anti-tumor effect of Holothuria leucospilota extract on hepatocellular carcinoma. Hepat Mon. 2015;15(12):e32278.
Seyid E, Shahzabi N, Barzegar M, Rahimi T, Ghasemi M, Motallebai A, et al. Toxicity effect of Holothuria leucospilota sea cucumber on cancerous mitochondria obtained from a rat model of hepatocellular carcinoma. Asian Pac J Cancer Prev. 2024;25(10):1377–83.
Raja MT, Yaacob NY, Zhiqin W, Osman Z, Lim CY, Rahman F, et al. Hepatocellular carcinoma: a local registry on risk factors, imaging patterns, treatment strategies, and overall survival. J Med Malay. 2021;76(2):151–6.
Roldan GA, Blomker J, Aby ES, Howard M, Connell R, Paterson M, et al. Hepatocellular carcinoma from a hepatologist’s perspective. Semin Interv Radiol. 2024;41(2):456–64.
Kubokewa S, Zagoroulya N, Ryb Y, Fedotova V, Andreeva N, Chayka O, et al. Chemotherapy and chemoembolization of patients with oncohepatopathy as risk factors for the development of myocardial dysfunction. J Clin Med Kazakhstan. 2023;20(3):2–8.
Wargaseta TL, Permana S, Lestari D, Raharjo E, Dewi PS, Widjajanti N, et al. Comparison of liver cancer treatment alternatives. Asian Sci Eng Technol Med J. 2024;40(5):198–203.
Wargaseta TL, Permana S, Widjajanti N, Sasmita H, Dejan F, Rahman F, et al. Role of sea cucumber active compounds against hepatocellular carcinoma as an anti-cancer agent. Curr Liver Res. 2023;13(4):421–6.
Wen H, Duan F, Xu Z, Zhang X, Guo Y, Liu J, et al. Chemical composition and antioxidant activities in the body wall of Holothuria scabra. J Sci Food Agric. 2010;90(13):2469–74.
Al Marzooqy I, Permana S, Widjajanti N, Sutisna T, Haryanto A, Dejan F, et al. Sea cucumber triterpene glycosides suppress cancer cell survival, migration, and invasion in vitro. Pharm Biol. 2023;61(2):25–34.
Zhao Q, Xue Y, Liu D, Zhang S, Wang Z, Xu C, et al. Differential study of sulfated triterpene glycosides from sea cucumbers and their bioactivity. Mar Drugs. 2014;12(2):797–816.
Seyid E, Motallebai A, Shahzabi N, Rahimi T, Barzegar M, Nematollahi S, et al. Holothuria scabra triterpenoid saponins as a potential anti-bladder cancer drug. Nutr Cancer. 2023;15(2):378–84.
Abdo AAA, Ifou Y, Hassan FA, Alnasser Z, Rahman MA, Elfadhl K, et al. Antioxidant potential and protective effect of modified sea cucumber peptides against H2O2-induced oxidative damage in HepG2 cells and in the zebrafish model. Int J Biol Macromol. 2024;242:131909.
Amimii DF, Menchiksaya ES, Pisliagin EA, Androsova I, Karev V, Borisova Y, et al. Anticancer activity of sea cucumber triterpene glycosides. Mar Drugs. 2013;11(3):1202–23.
Li XQ, Roginsky A, Ding X, Chen J, Zhao Y, Fan C, et al. Interdependent frondoside of sea cucumber Cucumaria frondosa inhibits proliferation of human pancreatic cells in vitro. Cancer Lett. 2004;210(3):215–21.
Wargaseta TL, Permana S, Widjajanti N, Raharjo E, Lestari D, Dewi PS, et al. Role of sea cucumber compounds as MDM2 and CXCR4 inhibitors on cancer stem cells. Integr Ther Med. 2023;40(3):6858–62.
Amidi S, Hashemi Z, Motallebai A, Shahzabi N, Rahimi T, Barzegar M, et al. The role of Holothuria scabra diphenylmethylsilanol in anti-cancer models in Perlisian GI system. Front Oncol. 2021;11:6858.
Latte-Noar AS, Karsenty C, Dupont P, Fernandez L, Cohen L, De Ville S, et al. Putting integrative oncology into practice: the holistic approach to cancer care. Integr Oncol J. 2024;33(5):445–59.
Warganata JS, Cohen L, De Ville S, Permana S, Widjajanti N, Raharjo E, et al. Integrative medicine in oncology: mechanisms and outcomes. Nat Rev Cancer. 2024;24(4):739–741.
Misghal T, Soewarta L, Nurmainish T, Wargaseta TL, Permana S, Widjajanti N, et al. Hepatoprotective potential of sea cucumber Holothuria scabra and its bioactive compounds against liver injury. Biomed J Mar Med. 2024;24(9):1065–72.
Salhindo N, Nurlofs F, Granwan WB, Rahman H, Wargaseta TL, Permana S, et al. Anticancer and antibacterial attributes of sea cucumbers: an opinion in terms of functional food applications. Front Nutr. 2022;9:986
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