The Association between The Patient’s Age Groups with Stage, Grading, and Molecular Subtype of Breast Cancer

Agatha MA Putri; Jayadi Tejo; Wiwiek Probowati; Jonathan W Siagian

doi:10.28932/jmh.v4i2.4554

Authors

Agatha MA Putri Faculty of Medicine Duta Wacana Christian University, Yogyakarta
Jayadi Tejo Medical Faculty of Universitas Kristen Duta Wacana
Wiwiek Probowati Pathological Anatomy of Bethesda Hospital Yogyakarta
Jonathan W Siagian Faculty of Medicine Duta Wacana Christian University, Yogyakarta

DOI:

https://doi.org/10.28932/jmh.v4i2.4554

Keywords:

breast cancer, clinicopathology profiles, age group

Abstract

In 2020, Global Cancer Observatory reported breast cancer incidence was 11.7% and mortality was 6.9%, most presenting a late-stage and delaying diagnosis. The study aimed to assess the breast cancer clinicopathologic characteristics according to the age groups. The research was conducted on 98 Medical Records from Bethesda Hospital Yogyakarta. The variable data were analyzed by univariate and the association between variables were analyzed with binary logistic regression with odds ratio and 95% confidence interval. The presentation of age groups ≤ 30 years (1,02%), 31-40 years (12,24%), 41-50 years (25,51%), 51-60 years (46,94%), and ≥ 61 years (15,31%); right breast (48,98%) and left breast (51,02%); stage I (3,06%), II (28,57%), III (55,10%), dan IV (13,27%); ductal type of breast cancer (89,80%) and others (10,20%); molecular subtype luminal A (43,88%), luminal B (14,29%), HER-2 neu enriched (29,59%), and basal-like/triple-negative (12,24%). There wasn’t any association between age groups and stages (p=0.368). There was an association between age groups and molecular subtype (p=0.013, OR 2.993 CI95% 1.239-7.230). Conclusions: The commonest clinicopathologic characteristic of breast cancer patients were in the age group 51-60 years, left breast, high stage, ductal type, and luminal A. Hormone receptors in breast cancer expressed more common in patients ≤50 years.

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