Peran Probiotik terhadap Perbaikan Gejala Motorik pada Pasien dengan Penyakit Parkinson: Sebuah Meta-Analisis
DOI:
https://doi.org/10.28932/jmh.v6i2.8805Keywords:
disbiosis, gejala motorik, metaanalisis, penyakit Parkinson, probiotikAbstract
Penyakit Parkinson merupakan penyakit neurodegeneratif paling sering diderita kedua setelah penyakit Alzheimer, yang ditandai dengan adanya bradikinesia, tremor saat istirahat, dan rigiditas. Penanda utama dari penyakit Parkinson adalah patologi α-synuclein yang disebut dengan Lewy Body. Beberapa penelitian terbaru menunjukkan peran gut dysbiosis menjadi salah satu faktor dalam patofisiologi penyakit Parkinson. Beberapa penelitan sebelumnya menunjukkan efektivitas probiotik terhadap perbaikan klinis penyakit Parkinson. Tujuan dari penelitian ini adalah untuk menganalisis peran probiotik terhadap gejala motorik pasien dengan penyakit Parkinson. Metode penelitian ini adalah dengan melakukan pencarian studi melalui berbagai database seperti Pubmed, Scopus, Cochrane, dan ProQuest. Studi yang didapatkan kemudian dilakukan skrining, penilaian kualitas studi, dan analisis kuantitatif. Hasil penelitian ini didapatkan total 5 studi yang melibatkan 339 pasien dengan penyakit Parkinson. Meta-analisis penelitian ini menunjukkan penurunan skor Unified Parkinson’s Disease Rating Scale Part III (UPDRS-III) secara signifikan (standardized mean difference: -0,25; interval kepercayaan 95%, -0,44 hingga -0,06) pada pasien dengan penyakit Parkinson setelah pemberian probiotik. Penelitian ini menunjukkan bahwa probiotik dapat memperbaiki gejala motorik secara signifikan pada pasien dengan penyakit Parkinson yang diukur dengan skala UPDRS-III, serta relatif aman dan dapat ditoleransi dengan baik.Downloads
References
de Lau LM, Breteler MM. Epidemiology of Parkinson’s disease. Lancet Neurol. 2006;5(6):525–35.
Ou Z, Pan J, Tang S, Duan D, Yu D, Nong H, et al. Global Trends in the Incidence, Prevalence, and Years Lived With Disability of Parkinson’s Disease in 204 Countries/Territories From 1990 to 2019. Front Public Heal. 2021;9:776847
Armstrong MJ, Okun MS. Diagnosis and Treatment of Parkinson Disease. JAMA. 2020;323(6):548.
DeMaagd G, Philip A. Parkinson’s Disease and Its Management: Part 1: Disease Entity, Risk Factors, Pathophysiology, Clinical Presentation, and Diagnosis. P T. 2015;40(8):504–32.
Klann EM, Dissanayake U, Gurrala A, Farrer M, Shukla AW, Ramirez-Zamora A, et al. The Gut–Brain Axis and Its Relation to Parkinson’s Disease: A Review. Front Aging Neurosci. 2022;13:782082
Li Z, Liang H, Hu Y, Lu L, Zheng C, Fan Y, et al. Gut bacterial profiles in Parkinson’s disease: A systematic review. CNS Neurosci Ther. 2023;29(1):140–57.
Romano S, Savva GM, Bedarf JR, Charles IG, Hildebrand F, Narbad A. Meta-analysis of the Parkinson’s disease gut microbiome suggests alterations linked to intestinal inflammation. npj Park Dis. 2021;7(1):00156
Natale G, Ryskalin L, Morucci G, Lazzeri G, Frati A, Fornai F. The Baseline Structure of the Enteric Nervous System and Its Role in Parkinson’s Disease. Life. 2021;11(8):732.
Scorza FA, de Almeida ACG, Scorza CA, Fiorini AC, Finsterer J. The microbiota in Parkinson’s disease: Natural products to help our clinical practice. Pharmacol Res. 2022;175:105984
Sampson TR, Debelius JW, Thron T, Janssen S, Shastri GG, Ilhan ZE, et al. Gut Microbiota Regulate Motor Deficits and Neuroinflammation in a Model of Parkinson’s Disease. Cell. 2016;167(6):1469-80.e12.
Hemarajata P, Versalovic J. Effects of probiotics on gut microbiota: mechanisms of intestinal immunomodulation and neuromodulation. Therap Adv Gastroenterol. 2013;6(1):39–51.
Ma T, Shen X, Shi X, Sakandar HA, Quan K, Li Y, et al. Targeting gut microbiota and metabolism as the major probiotic mechanism - An evidence-based review. Trends Food Sci Technol. 2023;138:178–98.
Hong CT, Chen JH, Huang TW. Probiotics treatment for Parkinson disease: a systematic review and meta-analysis of clinical trials. Aging (Albany NY). 2022;14(17):7014–25. doi: 10.18632/aging.204266
Sterne JAC, Savovic J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: A revised tool for assessing the risk of bias in randomized trials. BMJ. 2019;366:1–8.
Higgins J, Thomas J, Chandler J, Cumpston M, Li T, Page M, et al. Cochrane Handbook for Systematic Reviews of Interventions version 6.4. Cochrane; 2023.
Ghalandari N, Assarzadegan F, Habibi SAH, Esmaily H, Malekpour H. Efficacy of Probiotics in Improving Motor Function and Alleviating Constipation in Parkinson’s Disease: A Randomized Controlled Trial. Iran J Pharm Res. 2023;22(1):137840
Tamtaji OR, Taghizadeh M, Daneshvar Kakhaki R, Kouchaki E, Bahmani F, Borzabadi S, et al. Clinical and metabolic response to probiotic administration in people with Parkinson’s disease: A randomized, double-blind, placebo-controlled trial. Clin Nutr. 2019;38(3):1031–5.
Sun H, Zhao F, Liu Y, Ma T, Jin H, Quan K, et al. Probiotics synergized with conventional regimens in managing Parkinson’s disease. npj Park Dis. 2022;8(1):00327-6
Ibrahim A, Raja Ali RA, Abdul Manaf MR, Ahmad N, Tajurruddin FW, Qin WZ, et al. Multi-strain probiotics (Hexbio) containing MCP BCMC strains improved constipation and gut motility in Parkinson’s disease: A randomized controlled trial. PLoS One. 2020;15:0244680
Yang X, Zhou R, Di W, He Q, Huo Q. Clinical therapeutic effects of probiotics in patients with constipation associated with Parkinson's disease A protocol for systematic review and meta-analysis. Med (United States). 2021;100(44):27705
Lu CS, Chang HC, Weng YH, Chen CC, Kuo YS, Tsai YC. The Add-On Effect of Lactobacillus plantarum PS128 in Patients With Parkinson’s Disease: A Pilot Study. Front Nutr. 2021;8:650053
Tambun O, Marisdina S, Bahar E. Faktor-Faktor Yang Mempengaruhi Kualitas Hidup Penderita Penyakit Parkinson Dengan Menggunakan Parkinson’s Disease Questionnaire-39. Maj Kedokt Neurosains Perhimpun Dr Spes Saraf Indones. 2021;38(4).
Park JM, Lee SC, Ham C, Kim YW. Effect of probiotic supplementation on gastrointestinal motility, inflammation, motor, non-motor symptoms and mental health in Parkinson’s disease: a meta-analysis of randomized controlled trials. Gut Pathog. 2023;15(1).
Xie L, Chen D, Zhu X, Cheng C. Efficacy and safety of probiotics in Parkinson’s constipation: A systematic review and meta-analysis. Vol. 13, Frontiers in pharmacology. Switzerland; 2022. p. 1007654.
Forsyth CB, Shannon KM, Kordower JH, Voigt RM, Shaikh M, Jaglin JA, et al. Increased Intestinal Permeability Correlates with Sigmoid Mucosa alpha-Synuclein Staining and Endotoxin Exposure Markers in Early Parkinson’s Disease. Oreja-Guevara C, editor. PLoS One. 2011;6(12):e28032.
Ghosh SS, Wang J, Yannie PJ, Ghosh S. Intestinal Barrier Dysfunction, LPS Translocation, and Disease Development. J Endocr Soc. 2020;4(2).
Sorboni SG, Moghaddam HS, Jafarzadeh-Esfehani R, Soleimanpour S. A Comprehensive Review on the Role of the Gut Microbiome in Human Neurological Disorders. Clin Microbiol Rev. 2022;35(1).
Braak H, Tredici K Del, Rüb U, de Vos RA., Jansen Steur EN., Braak E. Staging of brain pathology related to sporadic Parkinson’s disease. Neurobiol Aging. 2003;24(2):197–211.
Holmqvist S, Chutna O, Bousset L, Aldrin-Kirk P, Li W, Björklund T, et al. Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats. Acta Neuropathol. 2014;128(6):805–20.
Kim C, Lv G, Lee JS, Jung BC, Masuda-Suzukake M, Hong CS, et al. Exposure to bacterial endotoxin generates a distinct strain of alpha-synuclein fibril. Sci Rep. 2016;6(1):30891.
Houser MC, Chang J, Factor SA, Molho ES, Zabetian CP, Hill-Burns EM, et al. Stool Immune Profiles Evince Gastrointestinal Inflammation in Parkinson’s Disease. Mov Disord. 2018;33(5):793-804.
Wang RX, Lee JS, Campbell EL, Colgan SP. Microbiota-derived butyrate dynamically regulates intestinal homeostasis through the regulation of actin-associated protein synaptopodin. Proc Natl Acad Sci. 2020;117(21):11648–57.
Fitzgerald E, Murphy S, Martinson HA. Alpha-synuclein pathology and the role of the microbiota in Parkinson’s disease. Front Neurosci. 2019;13:00369
Markowiak-Kopec P, Slizewska K. The Effect of Probiotics on the Production of Short-Chain Fatty Acids by Human Intestinal Microbiome. Nutrients. 2020;12(4):1107.
Zhang X, Chen S, Zhang M, Ren F, Ren Y, Li Y, et al. Effects of Fermented Milk Containing Lacticaseibacillus paracasei Strain Shirota on Constipation in Patients with Depression: A Randomized, Double-Blind, Placebo-Controlled Trial. Nutrients. 2021;13(7):2238.
Ait-Belgnaoui A, Durand H, Cartier C, Chaumaz G, Eutamene H, Ferrier L, et al. Prevention of gut leakiness by a probiotic treatment leads to attenuated HPA response to acute psychological stress in rats. Psychoneuroendocrinology. 2012;37(11):1885–95.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2024 Ferdinand Erwin, Meryana Meryana, Nita Kurniawati, Desy Kartikasari, Paulus A Supit
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Authors who publish with this journal agree to the following terms:
- Authors retain the copyright and grant the journal right of first publication with the work
simultaneously licensed under a Creative Commons Attribution-NonCommercial 4.0 International License that allows others to share the work with an acknowledgement of the work's authorship and initial publication in this journal. - Authors are able to enter into separate, additional contractual arrangements for the nonexclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal.
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
