Platelet-To-Lymphocyte Ratio as a Predictor of Disability Prognosis in Acute Ischemic Stroke Patients at Bethesda Hospital

Arya T Bagaskara; Rizaldy Pinzon; Pradita S Mitasari

doi:10.28932/jmh.v7i1.9809

Authors

Arya T Bagaskara Faculty of Medicine, Duta Wacana Christian University https://orcid.org/0009-0008-0423-7423
Rizaldy Pinzon Faculty of Medicine, Duta Wacana Christian University https://orcid.org/0000-0002-3357-9907
Pradita S Mitasari Faculty of Medicine, Duta Wacana Christian University

DOI:

https://doi.org/10.28932/jmh.v7i1.9809

Keywords:

acute ischemic stroke, platelet-to-lymphocyte ratio, stroke patients, stroke disability

Abstract

Stroke precipitates a neuroinflammatory response. Platelet-to-lymphocyte ratio (PLR) is an inflammatory biomarker conveying plaque adhesion and infarct volume. A high level of PLR is associated with stroke patient’s poor clinical outcomes. This study highlights PLR's potential as a predictive biomarker for post-stroke disability. This study aims to measure PLR at admission and to investigate its potential as a predictor for post-stroke disability. A retrospective cohort study was designed with 98 subjects from Bethesda Hospital Yogyakarta. ROC/AUC analyzed PLR to find the optimal cut-off value. Risk factors were analyzed to find the correlation and causality. From 98 patients, the optimal PLR cut-off is 146.86. A significant positive correlation was observed between PLR and modified Rankin Scale (mRS) scores (p=0.017), and National Institutes of Health Stroke Scale (NIHSS) scores (p=0.043). A significant mean difference in PLR values was also identified between mRS outcomes (p=0.017). PLR was a predictor for mRS (OR=4.051, p=0.037), although it did not predict NIHSS outcomes. The findings indicate that PLR is predictive of post-stroke disability in cases of ischemic stroke. An elevation in PLR suggests a disequilibrium between inflammatory mediators and neuroprotective factors. In conclusion, PLR has the potential as a predictor for post-stroke disability in ischemic stroke

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Author Biography

Rizaldy Pinzon, Faculty of Medicine, Duta Wacana Christian University

Lektor Kepala Universitas Kristen Duta Wacana Bidang Neurologi (Spesialis Saraf) RS Bethesda Yogyakarta

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