A Case of Pure Red Cell Aplasia as a Possible Complication of Pulmonary Tuberculosis Treatment

Abram P Tanuatmadja; Limdawati  Kwee; Fellicia Tan; Ardo  Sanjaya; Julia W Gunadi

doi:10.28932/jmh.v5i2.6682

Authors

Abram P Tanuatmadja Maranatha Christian University
Limdawati Kwee Maranatha Christian University
Fellicia Tan Maranatha Christian University
Ardo Sanjaya Maranatha Christian University
Julia W Gunadi Maranatha Christian University

DOI:

https://doi.org/10.28932/jmh.v5i2.6682

Keywords:

Pure red cell aplasia, tuberculosis, isoniazid, anemia, tuberculosis treatment

Abstract

Pure red cell aplasia (PRCA) is a rare disorder caused by failure or abnormalities in erythropoiesis only, among all cell lines of the bone marrow. Patients with PRCA usually present with no specific clinical presentation, thus its recognition depends on a clinician’s high index of suspicion, to facilitate early diagnosis and treatment to provide a better prognosis. Tuberculosis (TB) is the infectious disease with the highest casualty rate worldwide and is still a problem in many countries, including Indonesia. This study is a case report of a pulmonary TB patient with PRCA as a complication. PRCA was confirmed by the bone marrow puncture (BMP) examination as the gold standard. In this case, PRCA was inferred to occur due to the use of Isoniazid in the TB treatment regimen. The discontinuation of Isoniazid administration subsequently results in the normalization of Hb levels. In this paper we would highlight PRCA as a differential diagnosis that should be taken into consideration in symptomatic anemia in patients with tuberculosis under standard treatment.

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